Xiao Wang, Assistant Professor of Chemistry, MIT
In this presentation, I will describe a new method that merges sequencing and imaging to enable spatially resolved transcriptomics in 3D cellular context. I will also show the prospect to apply such methods in neuroscience to probe gene expression and determine causality at the single-cell resolution within intact neural networks that give rise to animal behaviors.
The Wang Group is developing and applying the state-of-the-art tools of chemistry, biophysics and genomics to map the brain from molecules to systems. In specific, with in situ sequencing of nucleic acids as the core approach, I aim to develop high-resolution and highly-multiplexed molecular imaging methods across multiple scales toward understanding the physical and chemical basis of brain wiring and function.