Topics in Bioengineering

Synthetic Hydrogels for Skeletal Muscle Regenerative Engineering

Woojin Han (Icahn School of Medicine at Mount Sinai)

Mar 9, 2023
12:00 pm to 1:00 pm | Maxwell Dworkin, 119 | Remote option

Function and regenerative potential of skeletal muscle decline with trauma, aging, and diseases, where the loss of muscle quality is attributed to reduced muscle stem (satellite) cell number and function. Inadequate regeneration of muscle in these conditions leads to debilitating consequences, including long-term disabilities and reduced quality of life. Although transplantation of muscle satellite cells is emerging as a promising strategy to enhance muscle regeneration, direct intramuscular injection of cells is limited by sub-optimal survival, retention, and engraftment. In this seminar, I will discuss approaches to systematically engineer a synthetic cell-instructive matrix that promotes primary muscle satellite cell function, including survival, proliferation, migration, and differentiation, as well as strategies to deliver muscle satellite cells and soluble therapeutics via the engineered hydrogel for treating muscle disorders, including injury, muscular dystrophy, and rotator cuff muscle disease.

Speaker Bio

Dr. Woojin Han is an Assistant Professor in the Leni and Peter W. May Department of Orthopaedics and a faculty member in the Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai. Dr. Han received his B.S. in Biomedical Engineering from the University of Rochester, and his M.S.E and Ph.D. in Bioengineering at the University of Pennsylvania. After completing this graduate work, he joined Andrés García’s laboratory at the Georgia Institute of Technology for his postdoctoral training. In 2021, he joined the Department of Orthopaedics at the Icahn School of Medicine at Mount Sinai as a tenure track Assistant Professor, where he leads the Laboratory for Cell-Instructive Biomaterials and Regenerative Engineering. Dr. Han’s research has been supported by multiple awards, including the National Institutes of Health (NIH) Ruth L. Kirschstein Postdoctoral Fellowship (F32), Glenn/American Federation for Aging Research Postdoctoral Fellowship for Translational Research on Aging, and is currently supported by the NIH Stephen I. Katz Early-Stage Investigator Research Project Grant (R01) and other collaborative research grants.


Douglas Woodhouse