33 Oxford Street, Cambridge, MA 02138

https://tib.seas.harvard.edu/

Function and regenerative potential of skeletal muscle decline with trauma, aging, and diseases, where the loss of muscle quality is attributed to reduced muscle stem (satellite) cell number and function. Inadequate regeneration of muscle in these conditions leads to debilitating consequences, including long-term disabilities and reduced quality of life. Although transplantation of muscle satellite cells is emerging as a promising strategy to enhance muscle regeneration, direct intramuscular injection of cells is limited by sub-optimal survival, retention, and engraftment. In this seminar, I will discuss approaches to systematically engineer a synthetic cell-instructive matrix that promotes primary muscle satellite cell function, including survival, proliferation, migration, and differentiation, as well as strategies to deliver muscle satellite cells and soluble therapeutics via the engineered hydrogel for treating muscle disorders, including injury, muscular dystrophy, and rotator cuff muscle disease.

  • Janet Van Der Graaf Mas
  • Jing Yang
  • Aditya Patil

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