Please contact Molly Kruki @ mkruko@mit.edu for the zoom login. 

Title: A quantitative gaze at blood cell production

Abstract: Hematopoiesis is the process by which hematopoietic stem and progenitor cells give rise to all blood cells. Hematopoietic cells can be divided into at least 13 cell types, corresponding to approximately tens of trillions of cells distributed among most tissues of the body. As most hematopoietic cells are short-lived, hematopoiesis is a constantly regenerating process. Moreover, hematopoiesis flux can vary in response to changing demands for blood cells in peripheral tissues, for example during bleeding or infection. Hematopoiesis starts from a few hematopoietic stem and progenitor cells (HSPC) to finally produce many mature cells. Understanding the mechanisms that allow the small pool of HSPCs to meet changing requirements for such large blood cell numbers remains a challenge. In this talk, I will present some general quantitative consideration of hematopoiesis and recent results on
quantifying cell dynamics in hematopoiesis.