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Cell surfaces present a diverse collection of lipids, proteins, and glycans that mediate interactions with the extracellular environment. Interfaces formed at junctions between cells are often associated with characteristic patterns of membrane protein organization. How cell surface molecules achieve this organization and what role it plays in downstream signaling underlies key aspects of tissue formation, target recognition by immune cells, and pathogen entry. This talk will introduce new methods for characterizing and manipulating cell surfaces to explore mechanisms of cell-cell contact formation, using examples from immunology and development.

  • Ben Levy

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