Applied Physics and Applied Mechanics Colloquia

Measuring is Revealing: Embracing New Biology Through Precision Measurements

Hee-Sun Han (University of Illinois at Urbana-Champaign)

Friday, Mar 22, 2024
11:00 am to 12:00 pm | Pierce Hall, 209 | Remote option

Recent advances in measurement technologies have revolutionized our ability to characterize biological systems at unprecedented resolution and scale. Our group strives to uncover important insights that can only be revealed by high resolution, high dimensional measurements. We leverage these discoveries to explore new frontiers of biology that would otherwise remain inaccessible. Specifically, we identify natural systems amenable to a reductionist analysis made possible by high precision, high content datasets, develop appropriate tools, and quantitatively characterize the fundamental mechanisms that govern the ensemble behavior of these systems. We have pioneered 'Single Virus Genomics' by developing microfluidic platforms that enable direct profiling of individual virus genomes, bypassing the need for virus culture. This technology allows large-scale, unbiased profiling of single virus genomes, enabling quantitative assessment of viral evolution and infection dynamics. I will present our technical innovations and the first demonstration of quantitative assessment of influenza reassortment between naturally circulating strains. In parallel, we are actively developing and applying spatial omics tools to leverage spatial information to identify the key molecular and cellular features that drive system-level phenotypes. I will briefly discuss the benefits of studying honeybee brains for comparative studies and the new biological insights revealed by high spatial resolution brain mapping.


AP/MSME Colloquium Series


Douglas Woodhouse