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X-WR-CALNAME:Design of Synthetic Alternatives to Biologics in Medicine
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260520T165615Z
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DTSTART:20210304T170000Z
DTEND:20210304T180000Z
DESCRIPTION:Register for the Topics in Bioengineering 2020-21 Series here (
 via Zoom). Registration is quick and easy\; you only have to sign up once 
 to receive the link that will be used for all TIB webinars this semester. 
 \n\n---\n\nBiologics\, products produced from living organisms\, have revo
 lutionized treatment of disease. Examples of FDA-approved biologics includ
 e therapeutic proteins (e.g. blood clotting factors and antibodies)\, engi
 neered viruses for gene therapy\, and cell therapies. Biologics are addres
 sing previous unmet medical needs\, but are challenging to manufacture and
  therefore high in cost. In this talk\, I will describe our efforts to dev
 elop synthetic alternatives to biologics used in medicine. In the first ex
 ample\, a multivalent polymer displaying a fibrin-binding peptide was deve
 loped as a synthetic alternative to recombinant proteins used in trauma me
 dicine. The second example\, a polymer that facilitates intracellular deli
 very of nucleic acids and peptides was synthesized based on design princip
 les learned from adenoviral vectors. In a final example\, a unique aptamer
  with high affinity for T cell marker CD8 was discovered and applied as an
  alternative to antibodies for T cell isolation in the manufacturing proce
 ss for CAR T cells.
LOCATION:Zoom
SUMMARY:Design of Synthetic Alternatives to Biologics in Medicine
URL;VALUE=URI:https://events.seas.harvard.edu/event/guest_speaker_suzie_pun
 _university_of_washington
CATEGORIES:Colloquia / Seminar / Lecture
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