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Eye drops are the dominant dosage form for the ocular route, and are used for a wide range of indications, including glaucoma, dry eye, inflammation, infection and allergy. However, as with all exposed epithelial surfaces, there are innate protective mechanisms that hinder efficient drug delivery to the eye. Thus, only a small fraction of drugs administered by eye drops is typically absorbed into the eye, often necessitating multiple doses per day. As the number of eye-drop doses per day increases, so does the potential for ocular surface irritation and systemic side effects, while patient compliance to the treatment regimen decreases. Here, I describe hypotonic gelling formulations that provide enhanced topical ocular drug delivery for a range of drugs for different ocular indications affecting both the anterior and posterior segment