Applied Physics and Applied Mechanics Colloquia

From Single Molecules To Cellular Decision Making: Connecting The Scales Using Mechanical Force

Taekjip Ha (Boston Children's Hospital & Harvard Medical School)

Friday, Feb 23, 2024
11:00 am to 12:00 pm | Pierce Hall, 209 | Remote option

In this lecture, I will describe our effort to understand how the mechanical responses of single molecules contribute to important cell fate decision, first in the nucleus where DNA resides and then on the cell membrane. We are revealing unusual mechanical properties of DNA that the evolution has utilized throughout the history of life on earth. We then repurpose the double helical structure of DNA to probe how the cells sense their mechanical environments.


AP/MSME Colloquium Series


Douglas Woodhouse