Engineering Microrobots for Tissue Probing, Biosensing, and Enhanced Drug Delivery
About this Event
Understanding the underlying factors driving tumor initiation, growth, and expansion is key to designing diagnostic and therapeutic tools, which then need to be delivered effectively. Using microrobots, we aim to shed light on mechanical cues that drive tumor proliferation, to develop mechanisms to sense and report biochemical disease cues, and to adequately shuttle therapeutics into tumor tissues for cancer therapy. In this talk I will present methods for 3D spatiotemporal probing of tumor tissue models to probe cellular responses and extract tissue mechanics via wireless control of magnetic microrobots. Further, I will share latest results on a protease responsive microrobot that is designed to acoustically report information about local proteolytic activity as disease biomarker. Lastly, I will show how we can engineer and effectively control swarms of living microrobots via scalable magnetic torque-based actuation using rotating magnetic fields (RMF). I will show how we can spatially restrict this actuation scheme to a single point using static magnetic gating fields and use simultaneous inductive detection for live feedback. Ultimately we are aiming with these concepts to reduce a patient’s systemic burden while increasing safety and therapeutic efficacy.
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